Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Interleukin 10 Receptor Beta Subunit (IL10RB)
- Target
- IL10RB
- Molecular classification
- Cytokine Receptor, Type II Cytokine Receptor, Receptor
01
Overview
The Interleukin 10 receptor beta subunit (IL10RB) is a shared cell surface receptor required for activation of five class II cytokines: IL-10, IL-22, IL-26, IL-28 (IFNλ2), and IFNL1/3. It acts as an accessory chain that is essential for forming functional heterodimeric or heterotetrameric cytokine receptors with various alpha subunits. Upon ligand binding, it initiates intracellular signaling via the JAK/STAT pathway, ultimately modulating gene transcription. Defects in IL10RB are associated with early-onset inflammatory bowel disease and other immunological disorders.
- Other names
- CDw210bCRF2-4CRFB4D21S58D21S66IL-10R2Interleukin 10 receptor subunit beta
02
Mechanism of action
Agonism or antagonism of IL-10, IL-22, IL-26, IL-28, or IFNL1/3 signaling pathways.
03
Biological functions
Signal transductionImmune responseAnti-inflammatory responseAntiviral activity regulation
04
Disease associations
Inflammatory bowel diseaseImmunodeficiencyAutoimmunity
05
Safety considerations
Potential for broad immune dysregulation if targeted systemically.Compromised immune response if completely inhibited, increasing risk of infection.Potential for cytokine storm if inappropriately activated
Beyond the preview
Go deeper on Interleukin 10 Receptor Beta Subunit (IL10RB).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Interleukin 10 Receptor Beta Subunit (IL10RB).