Interleukin-10 receptor subunit alpha (IL10RA)

Interleukin-10 receptor subunit alpha is a membrane-bound protein receptor that serves as the ligand-binding site for the anti-inflammatory cytokine interleukin-10 (IL-10). It is structurally related to interferon receptors and forms a heterotetrameric complex with the β subunit (IL10RB); this complex is primarily expressed on hematopoietic cells. Upon binding IL-10, the alpha subunit undergoes conformational changes that enable signal transduction through associated kinases JAK1 and TYK2, which phosphorylate STAT3, driving transcriptional changes that suppress proinflammatory cytokine synthesis and promote immune regulation. Genetic mutations in IL10RA have been linked to immunological disorders, notably early-onset inflammatory bowel syndromes and immune deficiencies. The receptor is a key modulator of mucosal and systemic immune responses and is considered a candidate for therapeutic intervention in autoimmune, inflammatory, and infectious diseases[1][2][3][7][8].

Other names

CDw210aCD210Interleukin-10 αInterleukin 10 receptor, alphaIL-10RA

Agonists: Enhance IL-10-mediated anti-inflammatory signaling, leading to inhibition of proinflammatory cytokine production and immune cell modulation (JAK1/TYK2/STAT3 pathway activation). Hypothetical antagonists: Would block IL-10 signaling, potentially increasing inflammation.