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Target intelligence / Profile preview
Interleukin-11 (IL-11)
- Target
- IL-11
- Molecular classification
- Cytokine, gp130/IL-6-type cytokine family
01
Overview
Interleukin-11 (IL-11) is a pleiotropic cytokine and a member of the IL-6-type cytokine family. It plays diverse roles across multiple tissues, including hematopoiesis support, inhibition of adipogenesis, regulation of embryo implantation, and modulation of bone metabolism. IL-11 signals via a receptor complex composed of IL-11Rα and the common co-receptor gp130, activating the JAK/STAT3 and MAPK/ERK pathways. Elevated IL-11 activity is implicated in fibro-inflammatory diseases and bone metabolic disorders. Recombinant human IL-11 (Oprelvekin) is used for chemotherapy-induced thrombocytopenia, but chronic exposure may pose pro-fibrotic risks.
- Other names
- IL11
02
Mechanism of action
Recombinant human IL-11 stimulates proliferation and maturation of hematopoietic stem cells and megakaryocyte progenitor cells, inducing megakaryocyte maturation
03
Biological functions
Hematopoiesis supportInhibition of adipogenesisRegulation of embryo implantationModulation of bone metabolismSignal transductionJAK/STAT3 pathway activationMAPK/ERK pathway activation
04
Disease associations
Fibrosis-related diseasesAutoimmune/inflammatory conditionsSystemic sclerosisRheumatoid arthritisPulmonary fibrosisInflammatory bowel diseaseKidney diseaseDrug-induced liver injuryNonalcoholic steatohepatitisBone metabolic disordersChronic gastroenteritisAsthma
05
Safety considerations
Potential toxicity with chronic exposure due to pro-fibrotic actionsSide effects associated with Oprelvekin
06
Interacting drugs
Oprelvekin
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