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Target intelligence / Profile preview
Interleukin-11 Receptor Subunit Alpha (IL11RA)
- Target
- IL11RA
- Molecular classification
- Receptor, Cytokine Receptor, Transmembrane Protein
01
Overview
Interleukin-11 receptor subunit alpha (IL11RA) is the ligand-binding component of the IL-11 receptor complex. Upon binding IL-11, it heterodimerizes with gp130, initiating intracellular signaling cascades involved in hematopoiesis, inflammation, bone development, and other biological processes. Dysregulation of IL11RA signaling has been implicated in various diseases, including craniosynostosis, fibrosis, and cancer, making it a potential therapeutic target.
- Other names
- CRSDAInterleukin 11 receptor alpha subunitInterleukin 11 receptor subunit alpha
02
Mechanism of action
IL11RA binds IL-11, forming a complex that associates with gp130, activating downstream signaling pathways like JAK/STAT.
03
Biological functions
Cytokine-mediated signaling pathwayInterleukin-11 bindingSignal transductionRegulation of skeletogenic progenitor cell proliferation/differentiationMesenchymal cell regulationRegulation of bone developmentTooth development regulation
04
Disease associations
Craniosynostosis syndromesFibrotic diseasesCancerDevelopmental disordersInflammation
05
Safety considerations
Potential for developmental abnormalities due to disruption of IL-11 signaling.Dysregulation linked to fibrotic diseases and cancer.
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