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Target intelligence / Profile preview
Interleukin-13 (IL-13)
- Target
- IL-13
- Molecular classification
- Cytokine, Signaling protein
01
Overview
Interleukin-13 (IL-13) is a cytokine primarily secreted by Th2 cells, mast cells, and other immune cells. It plays a crucial role in allergic inflammation, particularly in asthma and atopic dermatitis, by promoting IgE synthesis, mucus hypersecretion, airway hyperresponsiveness, and tissue fibrosis. It signals through the IL-4Rα/IL-13Rα1 receptor complex, activating the JAK/STAT6 pathway. IL-13 is also involved in defense against parasitic infections and contributes to various pathological processes, including ulcerative colitis, eosinophilic esophagitis, and certain cancers. Therapies targeting IL-13 are being developed for a range of inflammatory and fibrotic diseases.
- Other names
- IL13
02
Mechanism of action
Inhibition of IL-13 signaling, typically by blocking IL-13 binding to its receptor or neutralizing IL-13 directly.
03
Biological functions
Regulation of IgE synthesisGoblet cell hyperplasia and mucus hypersecretionAirway hyperresponsivenessTissue fibrosisRegulation of immune responsesDefense against parasitic infectionsModulation of B cell function
04
Disease associations
AsthmaAtopic dermatitisAllergic rhinitisUlcerative colitisEosinophilic esophagitisFibrotic diseasesCertain cancersAllergic inflammation
05
Safety considerations
Potential for immunosuppressionRisk of infectionUnintended consequences on immune homeostasis
06
Interacting drugs
Anti-IL-13 drugs (in development/testing)
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