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Target intelligence / Profile preview
Interleukin 13 Receptor Alpha 2
- Molecular classification
- Receptor, Single-pass type I membrane protein
01
Overview
Interleukin 13 Receptor Alpha 2 (IL-13Rα2) is a high-affinity receptor for interleukin-13 (IL-13). It primarily functions as a decoy receptor, sequestering free IL-13 to inhibit IL-4 and IL-13 mediated signaling. Overexpression in certain cancers has linked it to tumor invasion and metastasis, making it a therapeutic target.
- Other names
- IL-13Rα2CD213A2CT19IL13BPInterleukin-13 receptor subunit alpha-2
02
Mechanism of action
Monoclonal antibodies against IL-13Rα2; Chimeric antigen receptor T-cell therapies targeting IL-13Rα2 expressing tumor cells
03
Biological functions
Decoy receptorModulates Th2 immunityLigand internalizationImmune regulation
04
Disease associations
CancerInflammation
05
Safety considerations
Potential for off-target effects due to low expression in some normal tissues
06
Biomarkers
Diagnostic marker of malignancy/aggressiveness in solid tumorsPrognostic indicator of poor outcome in solid tumors
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