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Target intelligence / Profile preview
Interleukin-13 receptor subunit alpha-1 (IL13RA1)
- Target
- IL13RA1
- Molecular classification
- Receptor, Cytokine receptor, Membrane protein, Member of the IL-2 receptor family
01
Overview
Interleukin-13 receptor subunit alpha-1 (IL13RA1) is a transmembrane cytokine receptor that binds interleukin-13 (IL-13) with low affinity and, together with the IL-4 receptor alpha (IL4RA) subunit, forms a functional receptor complex for both IL-4 and IL-13. This receptor is pivotal in mediating pro-inflammatory signaling in immune cells through activation of the JAK/STAT pathway, especially STAT6, and is involved in regulating inflammatory and immune responses. Its expression is associated with modulation of airway inflammation (e.g., asthma), allergic conditions, and some cancers, and targeting this molecule is a subject of therapeutic investigation notably in allergy, asthma, and oncology.
- Other names
- IL-13 receptor subunit alpha-1IL-13RA1CD213A1CT19Cancer/testis antigen 19IL13 receptor alpha-1 chain
02
Mechanism of action
Blockade of IL-13 binding to IL13RA1; Inhibition of downstream JAK/STAT signaling; Modulation of immune/inflammatory response; Downregulation of allergic and fibrotic pathways.
03
Biological functions
Signal transductionImmune responseRegulation of inflammationMediation of cytokine signaling (IL-13 and IL-4)Activation of JAK/STAT pathway (specifically STAT3 and STAT6)
04
Disease associations
Cancer (lung cancer prognosis marker)InflammationAsthma (receptor upregulated in asthmatic bronchial tissue)Allergic diseaseAutoimmune disease
05
Safety considerations
Suppressing IL-13 signaling may impair host defense, particularly against parasitic infections and some immune challenges.Potential risk of immunosuppression.Balancing therapeutic impact and immune homeostasis is critical.
06
Interacting drugs
Monoclonal antibodies (under research, no specific marketed drugs named)
1 more in the full profile.
07
Biomarkers
IL13RA1 tissue expression (bronchial mast cells in asthma)Serum or tissue IL13RA1 for prognosis in some cancers (lung cancer)Not a routine clinical biomarker, but evaluated in research
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