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Target intelligence / Profile preview
Interleukin-13 Receptor Subunit Alpha 2 (IL13Rα2)
- Target
- IL13Rα2
- Molecular classification
- Receptor, Cytokine Receptor, Single-Pass Type I Membrane Protein
01
Overview
Interleukin-13 receptor subunit alpha 2 (IL13Rα2) is a membrane-bound protein that binds interleukin-13 (IL-13) with high affinity. Traditionally considered a decoy receptor that inhibits interleukin‑4 and interleukin‑13 mediated JAK/STAT signaling pathways. Recent evidence shows that in cancer cells, it can mediate pro-tumorigenic signaling, promoting invasion and metastasis. It is overexpressed in various cancers, making it an attractive target for anti-cancer therapies.
- Other names
- CD213A2CT19IL-13RIL13BPInterleukin 13 binding protein
02
Mechanism of action
Decoy receptor inhibiting JAK/STAT pathway; Pro-tumorigenic signaling via AP-1 or ERK/MAPK cascades when overexpressed.
03
Biological functions
Signal transductionImmune responseCell proliferationLigand bindingDecoy receptor activityRegulation of JAK/STAT signaling pathwayPromoting invasion and metastasis
04
Disease associations
CancerGlioblastoma multiformePancreatic cancerOvarian cancerMelanomaColorectal cancerBreast cancerTumor progressionMetastasis
05
Safety considerations
Potential for off-target effects if therapeutic targeting is not specific to tumor cellsRisk of immune-related adverse events with CAR T-cell therapy
06
Biomarkers
IL13Rα2 expression level
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