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Target intelligence / Profile preview
Interleukin 13 signaling via IL-4 receptor alpha
- Molecular classification
- Receptor, Cytokine Receptor, Type II Cytokine Receptor
01
Overview
Interleukin-13 (IL-13) signaling via the IL-4 receptor alpha (IL-4Rα) primarily occurs through the type II receptor complex, composed of IL-4Rα and IL-13Rα1. IL-13 binds to IL-13Rα1, which then recruits IL-4Rα to form the functional receptor. This complex activates downstream signaling pathways, notably the JAK/STAT6 pathway, leading to gene expression changes associated with Th2 responses, alternative macrophage activation, and the promotion of allergic inflammation, airway hyperresponsiveness, and fibrosis. IL-13Rα2 acts as a decoy receptor, attenuating IL-13 signaling.
- Other names
- Type II interleukin-four/interleukin-thirteen receptorType II cytokine receptor family member
02
Mechanism of action
Blocking IL-13 binding to the IL-4R alpha/IL-13R alpha1 receptor complex, inhibiting downstream signaling.
03
Biological functions
Signal transductionImmune responseAlternative macrophage activationRegulation of airway hyperreactivity and mucus secretionFibrosis developmentWound healing
04
Disease associations
AsthmaAllergyInflammatory bowel diseaseFibrotic disorders
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