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Target intelligence / Profile preview
Interleukin 15 Receptor Alpha (None)
- Target
- None
- Molecular classification
- Receptor, Single-pass type I membrane protein
01
Overview
Interleukin 15 receptor alpha (IL-15Rα) is a high-affinity binding subunit of the interleukin-15 (IL-15) receptor complex. It plays a crucial role in mediating the biological activities of IL-15, particularly in immune cell development and function. IL-15Rα primarily functions by presenting bound IL-15 "in trans" to neighboring immune cells expressing only βγ chains. Dysregulation has been implicated in cancer progression and immunity modulation.
- Other names
- IL-15RαCD215Interleukin 15 receptor, alpha subunit
02
Mechanism of action
Soluble IL-15Rα fragments can act as antagonists by inhibiting IL-15 signaling.
03
Biological functions
Signal transductionImmune responseCell proliferationCell survivalHomeostasis of T-cells and NK-cellsTrans-presentation of IL-15
04
Disease associations
CancerAutoimmune diseaseInflammationTransplantation
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