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Target intelligence / Profile preview
Interleukin 15 Receptor Alpha Chain (IL-15Rα)
- Target
- IL-15Rα
- Molecular classification
- Receptor, Single-pass type I membrane protein
01
Overview
The Interleukin 15 receptor alpha chain (IL-15Rα), also known as CD215, is a high-affinity binding subunit of the interleukin-15 (IL-15) receptor complex. IL-15Rα plays a central role in mediating the biological activities of IL-15, particularly in immune cell development and function. The primary function of IL‑15Rα is not only as part of a signaling complex but also as a presenter ("trans-presentation").
- Other names
- CD215IL15RAInterleukin‐十五受体亚基alpha（中文）
02
Mechanism of action
Targeting or harnessing this axis has become an area for cancer immunotherapy research. Blocking overactive signaling may be relevant in autoimmune/inflammatory diseases where excessive NK/T-cell activity contributes pathology.
03
Biological functions
Signal transductionImmune responseCell proliferationNatural killer (NK) cell proliferation/survival/maturationMemory CD8+ T-cell maintenance/homeostasis/proliferationNKT/intraepithelial lymphocyte development/functioningTrans-presentation
04
Disease associations
CancerAutoimmune diseasesInflammatory diseasesInfections
05
Safety considerations
Overactive signaling can contribute to autoimmune/inflammatory diseases.Dysregulation impacts immune surveillance against infections/tumors.
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