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Target intelligence / Profile preview
Interleukin-15 Receptor Alpha Subunit Complex (IL-15Rα)
- Target
- IL-15Rα
- Molecular classification
- Receptor, Cytokine Receptor, Single-pass type I membrane protein
01
Overview
The Interleukin-15 receptor alpha subunit (IL-15Rα) is a component of the interleukin-15 (IL-15) receptor complex and plays a critical role in immune system regulation. The functional IL-15 receptor complex consists of IL-15Rα, CD122 (IL2/IL15Rβ), and CD132 (common γ chain). IL-15Rα is unique to the IL-15 receptor and responsible for high-affinity binding to IL-15. It plays key roles in proliferation/survival/differentiation of memory CD8+ T-cells, development/functionality of natural killer (NK) cells, and modulation of innate/adaptive immunity. Due to its central role in immunoregulation, it is a therapeutic target for oncology/infectious disease/autoimmunity.
- Other names
- CD215Interleukin 15 Receptor Alpha Subunit
02
Mechanism of action
Agonist or antagonist of IL-15 signaling
03
Biological functions
Signal transductionImmune responseCell proliferationCell survivalT cell differentiationNK cell developmentImmunomodulation
04
Disease associations
CancerInfectionAutoimmunityInflammationTransplant rejection
05
Safety considerations
Excessive immunostimulationCytokine release syndromePotential for off-target effects due to shared receptor subunits
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