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Target intelligence / Profile preview
Interleukin 15 Receptor Beta Chain (IL-15Rβ)
- Target
- IL-15Rβ
- Molecular classification
- Receptor, Cytokine Receptor, Type I cytokine receptor family
01
Overview
The Interleukin 15 Receptor Beta Chain (IL-15Rβ) is a component of the receptor complexes for both interleukin-15 (IL-15) and interleukin-2 (IL-2). It is shared with the IL-2 receptor complex and is critical for signal transduction, playing key roles in lymphocyte proliferation, NK-cell maturation, memory CD8+ T-cell maintenance, and inflammatory responses. It signals through the JAK/STAT, PI3K/Akt/mTOR, and MAPK pathways. It is a therapeutic target for cancer immunotherapy, where IL-15 superagonists are being explored.
- Other names
- CD122IL2RBIL-2/15RβIL15RB
02
Mechanism of action
Agonist; Receptor subunit involved in signal transduction via JAK/STAT, PI3K/Akt/mTOR, and MAPK pathways
03
Biological functions
Signal transductionLymphocyte proliferationNK-cell maturationMemory CD8+ T-cell maintenanceImmune responseCell survivalCell proliferationAnti-tumor immunityAntiviral responsesInflammation
04
Disease associations
CancerInflammationAutoimmune diseasesInfection
05
Safety considerations
Potential for immune-related adverse events due to broad immune activationCytokine release syndrome
06
Interacting drugs
IL-15
2 more in the full profile.
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