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Target intelligence / Profile preview
Interleukin 15 Receptor Beta Subunit (IL15RB)
- Target
- IL15RB
- Molecular classification
- Receptor, Type I membrane protein
01
Overview
The interleukin 15 receptor beta subunit (IL15RB), also known as the interleukin 2 receptor beta chain (IL2RB) and CD122, is a type I membrane protein and a shared signaling component for both the interleukin 2 (IL-2) and interleukin 15 (IL-15) receptors. It plays a crucial role in mediating immune responses, particularly those involving T cells and natural killer (NK) cells. Activation via this receptor complex increases proliferation, especially among CD8+ effector T-cells and NK-cells, key players in anti-tumor immunity and viral defense responses. The receptor exists as part of heterotrimeric complexes, using distinct alpha chains for cytokine specificity but the same beta (IL15RB/CD122) and gamma common (γc) chains for signal transduction.
- Other names
- IL2RBInterleukin-2 receptor subunit betaCD122P70-75High affinity IL-2 receptor subunit betaIL-2/15Rβ
02
Mechanism of action
Agonist or antagonist modulation of IL-2 and IL-15 signaling
03
Biological functions
Signal transductionImmune responseCell proliferationCell survivalT cell activationNK cell activation
04
Disease associations
CancerViral infectionsAutoimmune diseases (potential)
05
Safety considerations
Potential for immune-related adverse eventsCytokine release syndrome (CRS)
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