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Interleukin-15 Receptor Fusion Protein (IL-15R Fusion Protein)
- Target
- IL-15R Fusion Protein
- Molecular classification
- Fusion Protein, Immunotherapeutic Agent, Cytokine, Receptor Ligand
01
Overview
Interleukin-15 receptor fusion proteins are engineered biologic molecules that combine interleukin-15 (IL-15) or its receptor subunits with other functional domains to enhance its therapeutic potential in cancer immunotherapy. These fusion proteins aim to improve IL-15's stability, half-life, tumor-targeting ability, and immunostimulatory effects while reducing systemic toxicity. Common features include IL-15/IL-15Rα complex, Fc fragment, and targeting motifs (e.g., RGD).
- Other names
- IL-15/IL-15Rα Fusion ProteinRGD-Fc-(IL-15/IL-15Rα)ALT-803PFC-1BioLink001HCW9218
02
Mechanism of action
Stimulates proliferation and activation of cytotoxic CD8+ T cells and natural killer (NK) cells, leading to increased anti-tumor immunity. Targets tumors via integrins or antibody-antigen interactions.
03
Biological functions
Immune StimulationT cell activationNK cell activationTumor TargetingJAK/STAT pathway activation
04
Disease associations
Cancer
05
Safety considerations
Systemic toxicityOff-target effects
06
Interacting drugs
Checkpoint inhibitors
1 more in the full profile.
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