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Target intelligence / Profile preview
Interleukin 15 Receptor Gamma Chain (γc)
- Target
- γc
- Molecular classification
- Receptor, Cytokine Receptor Subunit, Type I cytokine receptor family
01
Overview
The interleukin-15 receptor gamma chain (γc or CD132) is a crucial component of the IL-15 receptor and other cytokine receptors (IL-2, IL-4, IL-7, IL-9, and IL-21). It is essential for signal transduction, activating JAK kinases and STAT proteins. Its dysfunction leads to immunodeficiency, while overactivation may contribute to autoimmunity or cancer.
- Other names
- Common gamma chainCD132IL-2RγIL2RG
02
Mechanism of action
JAK/STAT pathway activation, PI3K/Akt/mTOR pathway activation, Ras/Raf/MAPK pathway activation
03
Biological functions
Signal transductionLymphocyte developmentLymphocyte homeostasisLymphocyte proliferationLymphocyte survivalImmune responseNK cell development and homeostasisMemory CD8+ T cell proliferation/survivalModulation of inflammatory responses
04
Disease associations
Severe Combined Immunodeficiency (SCID)Autoimmune disease (potential)Cancer (potential)
05
Safety considerations
Potential for off-target effects due to shared receptor usageRisk of immune dysregulationPotential for promoting cancer cell survival/proliferation
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