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Target intelligence / Profile preview
Interleukin-15 receptor subunit alpha isoform 1 (IL15RA)
- Target
- IL15RA
- Molecular classification
- Receptor, Cytokine Receptor, Type I cytokine receptor
01
Overview
Interleukin-15 receptor alpha subunit isoform 1 is a component of the interleukin-15 (IL-15) receptor complex. It plays a critical role in immune system regulation by binding IL-15 with very high affinity and presenting it to other cells for signaling. The receptor complex consists of IL-2/IL-15Rβ (CD122), common γ chain (CD132), and the unique α-chain: IL‑15Rα. The α-chain confers high-affinity binding to IL‑15 and contains an extracellular Sushi domain essential for ligand interaction. Soluble forms of IL-15Rα are being explored therapeutically for autoimmune diseases or transplant rejection prevention.
- Other names
- CD215Interleukin 15 receptor, alpha subunitInterleukin 15 receptor subunit alpha
02
Mechanism of action
Soluble forms can inhibit inflammatory responses by sequestering free cytokine.
03
Biological functions
Ligand bindingSignal transductionImmune responseLymphocyte developmentLymphocyte survivalLymphocyte proliferationLymphocyte activationCell-cell communicationIn trans presentation of IL-15
04
Disease associations
Autoimmune diseasesTransplant rejectionChronic inflammationCancerLarge granular lymphocyte leukemiaCutaneous T-cell lymphoma
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