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Target intelligence / Profile preview
Interleukin 17 Receptor (IL-17R)
- Target
- IL-17R
- Molecular classification
- Cytokine Receptor, Type I transmembrane protein
01
Overview
The Interleukin-17 receptor (IL-17R) is a cytokine receptor that binds members of the IL-17 family, primarily mediating proinflammatory responses. It plays a crucial role in host defense against extracellular pathogens and is implicated in the pathogenesis of various autoimmune and inflammatory diseases. Functional receptors are typically heteromeric complexes formed by combinations of IL‑17RA, IL‑17RB, IL‑17RC, IL‑17RD, and IL‑17RE subunits. Upon ligand binding, these receptors activate several intracellular signaling cascades including TRAF6, MAP kinases, and NF–κB, leading to induction of chemokines, G-CSF, antimicrobial peptides, and pro-inflammatory cytokines.
- Other names
- IL17RIL-17 ReceptorIL-17 Receptor Family
02
Mechanism of action
IL-17R antagonists block IL-17 signaling by preventing ligand-receptor interaction or downstream signaling events.
03
Biological functions
Signal transductionImmune responseNeutrophil recruitmentInflammationBarrier functionTissue remodeling
04
Disease associations
Autoimmune diseasesInflammatory disordersPsoriasisRheumatoid arthritisInflammatory bowel diseaseMultiple sclerosis
05
Safety considerations
Increased risk of infection due to immunosuppression.Potential for off-target effects due to broad expression of IL-17RA.
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