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Target intelligence / Profile preview
Interleukin 17 Receptor A (IL-17RA)
- Target
- IL-17RA
- Molecular classification
- Type I membrane glycoprotein, Cytokine receptor
01
Overview
Interleukin 17 receptor A (IL-17RA), also known as CDw217, is a type I membrane glycoprotein and a member of the cytokine receptor family. It serves as the primary receptor for interleukin 17A (IL-17A), a proinflammatory cytokine secreted by activated T lymphocytes. Binding of proinflammatory cytokines like interleukin 17A to this receptor triggers conformational changes that allow recruitment of adaptor proteins such as Act1 or TRAF proteins, leading to activation of NF‐κB, MAPK, and C/EBP pathways, resulting in increased production of inflammatory mediators.
- Other names
- CDw217IL17RA
02
Mechanism of action
Blocking or inhibiting the activity/signaling through IL-17RA
03
Biological functions
Signal transductionImmune responseNeutrophil mobilization/recruitmentAntimicrobial peptide production
04
Disease associations
PsoriasisRheumatoid arthritisChronic mucocutaneous candidiasisAutoimmune diseasesInflammatory diseases
05
Safety considerations
Increased risk of specific infections due to impaired neutrophil recruitment/antimicrobial peptide production
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