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Target intelligence / Profile preview
Interleukin-17 receptor E (IL-17RE)
- Target
- IL-17RE
- Molecular classification
- Receptor, Cytokine receptor family (specifically, interleukin 17 receptor family), Transmembrane protein
01
Overview
Interleukin‑17 receptor E is a member of the interleukin‑17 receptor family, which consists of several structurally related transmembrane proteins involved in immune signaling. IL‑17RE acts as a specific functional receptor for the cytokine interleukin‑17C. Upon ligand binding, it signals through intracellular pathways such as NF-kappa-B and MAPK, requiring the adaptor protein TRAF3IP2/ACT1 for downstream signaling[4]. This pathway plays an important role in mucosal barrier immunity and host defense against pathogens at epithelial surfaces[2]. IL‑17RE is highly expressed in Th17 cells and contributes to immune responses by mediating pro-inflammatory signals that help maintain tissue integrity during infection or inflammation[1][4].
- Other names
- IL-17REInterleukin 17 receptor EIl17re (gene/protein symbol, especially in mouse)
02
Biological functions
Signal transductionImmune response (especially mucosal immunity)Activation of NF-kappa-B and MAPK pathways
03
Disease associations
InflammationInfection (notably mucosal barrier defense)
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