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Target intelligence / Profile preview
Interleukin-17A (IL-17A)
- Target
- IL-17A
- Molecular classification
- Cytokine, Interleukin
01
Overview
Interleukin-17A (IL-17A) is a proinflammatory cytokine and a key member of the IL-17 cytokine family. It plays crucial roles in both innate and adaptive immunity, particularly in host defense against bacterial and fungal infections as well as in the pathogenesis of various autoimmune and inflammatory diseases. It induces chemokines that recruit neutrophils and monocytes to sites of inflammation, stimulates production of antimicrobial peptides by epithelial tissues, and promotes secretion of proinflammatory mediators.
- Other names
- CTLA8IL17A
02
Mechanism of action
Neutralization of IL-17A, preventing its binding to the IL-17 receptor and subsequent downstream signaling.
03
Biological functions
Immune responseNeutrophil recruitmentChemokine inductionProinflammatory mediator inductionAntimicrobial peptide productionAcute phase responseMucosal barrier maintenance
04
Disease associations
Autoimmune diseasesPsoriasisRheumatoid arthritisMultiple sclerosisInflammatory bowel diseasePeriodontitisCardiovascular diseaseAtherosclerosisHypertensionNeurodegenerative disease
05
Safety considerations
Increased risk of infections due to impaired neutrophil responses
06
Interacting drugs
Secukinumab
2 more in the full profile.
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