Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Interleukin-17A and Interleukin-17F (IL-17A/IL-17F)
- Target
- IL-17A/IL-17F
- Molecular classification
- Cytokine, Interleukin, Growth factor
01
Overview
Interleukin-17A (IL-17A) and Interleukin-17F (IL-17F) are closely related pro-inflammatory cytokines belonging to the interleukin 17 family. Both are primarily produced by T helper 17 (Th17) cells, but can also be secreted by a variety of other immune and non-immune cell types. They function as disulfide-linked homodimers or as an IL‑17A/IL‑17F heterodimer, signaling through the IL-17RA/IL-17RC receptor complex to induce the production of pro-inflammatory mediators, recruit neutrophils, maintain tissue barriers, and contribute to tissue remodeling. Dysregulation of IL-17A and IL-17F is associated with various chronic immune-mediated inflammatory diseases.
- Other names
- IL17AIL17FInterleukin 17AInterleukin 17F
02
Mechanism of action
Monoclonal antibodies that bind to IL-17A, IL-17F, or the IL-17 receptor, thereby blocking their interaction with the receptor and inhibiting downstream signaling pathways.
03
Biological functions
Immune responseInflammationNeutrophil recruitmentGranulopoiesisTissue barrier maintenanceTissue remodelingInduction of pro-inflammatory mediatorsCell signaling
04
Disease associations
PsoriasisPsoriatic arthritisAxial SpondyloarthritisInflammatory Bowel DiseaseAsthmaHidradenitis SuppurativaAutoimmune diseasesInflammatory diseases
05
Safety considerations
Increased risk of infections, particularly fungal infectionsPotential for exacerbation of inflammatory bowel disease in some patientsInjection site reactionsHypersensitivity reactionsImmunogenicity
06
Interacting drugs
Secukinumab
2 more in the full profile.
07
Biomarkers
Serum IL-17A levelsIL-17F levels in affected tissuesNeutrophil count
Beyond the preview
Go deeper on Interleukin-17A and Interleukin-17F (IL-17A/IL-17F).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Interleukin-17A and Interleukin-17F (IL-17A/IL-17F).