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Target intelligence / Profile preview
Interleukin 17A Receptor Subunit A (IL-17RA)
- Target
- IL-17RA
- Molecular classification
- Cytokine receptor, Type I transmembrane protein, Interleukin receptor
01
Overview
Interleukin 17A receptor subunit A (IL-17RA) is a transmembrane protein that serves as the primary receptor for interleukin-17A (IL-17A), a proinflammatory cytokine. IL-17RA is the founding member of the IL-17 receptor family. Upon ligand binding (IL-17A or IL-17F), IL-17RA forms a heteromeric complex (typically with IL-17RC or IL-17RD), leading to activation of intracellular signaling pathways and the production of pro-inflammatory mediators. It plays a crucial role in host defense and the pathogenesis of chronic inflammatory diseases.
- Other names
- IL17RA
02
Mechanism of action
Blocking the interaction of IL-17A with its receptor IL-17RA, thereby inhibiting downstream signaling pathways like NFκB and MAPK, and reducing the production of pro-inflammatory mediators.
03
Biological functions
Signal transductionImmune responseNeutrophil recruitmentHost defenseInflammation
04
Disease associations
PsoriasisRheumatoid arthritisPeriodontitisInflammatory bowel disease (IBD)Autoimmune diseases
05
Safety considerations
Potential for immunosuppressionIncreased risk of infection
06
Interacting drugs
Drugs blocking the IL-17A/IL-17RA pathway
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