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Target intelligence / Profile preview
Interleukin 17AF Complex (IL-17AF)
- Target
- IL-17AF
- Molecular classification
- Cytokine, Interleukin, Heterodimer
01
Overview
The Interleukin 17AF (IL-17AF) complex is a heterodimeric cytokine composed of IL-17A and IL-17F, primarily produced by Th17 cells. It binds to the IL-17RA/IL-17RC receptor complex, inducing pro-inflammatory responses by activating NF-kB and stabilizing mRNA. IL-17AF plays a role in host defense against extracellular pathogens but is also implicated in the pathogenesis of autoimmune and inflammatory diseases. Its activity lies intermediate between IL-17A and IL-17F homodimers, and it is a target for therapeutic antibodies in conditions like psoriasis and spondyloarthritis.
- Other names
- IL17AFInterleukin-17AF
02
Mechanism of action
IL-17AF binds to the IL-17RA/IL-17RC receptor complex, activating downstream signaling pathways including NF-kB and mRNA stabilization, leading to pro-inflammatory gene expression and chemokine production.
03
Biological functions
Immune responseInflammationChemokine productionNeutrophil recruitmentInnate immune defenseTissue remodelingAntimicrobial peptide inductionSignal transduction
04
Disease associations
InflammationAutoimmune diseasePsoriasisSpondyloarthritisInfectionPsoriatic arthritisAnkylosing spondylitis
05
Safety considerations
Increased risk of infectionExacerbation of inflammatory conditionsPotential for off-target effects due to targeting shared subunits (IL-17RA)
06
Interacting drugs
Therapeutic antibodies targeting IL-17A
4 more in the full profile.
07
Biomarkers
IL-17A levelsIL-17F levelsCXCL1 levelsCXCL2 levelsCXCL8 levels
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