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Target intelligence / Profile preview
Interleukin 17AF Heterodimer
- Molecular classification
- Cytokine, Interleukin, Heterodimer
01
Overview
Interleukin 17AF (IL-17AF) is a cytokine heterodimer composed of IL-17A and IL-17F subunits. It is secreted by Th17 cells and plays a crucial role in mediating inflammatory responses by binding to the IL-17RA/IL-17RC receptor complex and activating downstream signaling pathways that lead to the production of pro-inflammatory mediators. It is implicated in the pathogenesis of autoimmune diseases and other inflammatory conditions.
02
Mechanism of action
Signaling through IL-17RA/IL-17RC receptor complex, activating Act1-TRAF6-NFκB/MAPK pathways
03
Biological functions
Immune responseInflammationChemokine inductionNeutrophil recruitment
04
Disease associations
InflammationAutoimmune diseasesRheumatoid arthritisImmune-mediated inflammatory diseases (IMIDs)
05
Safety considerations
Potential for broad immunosuppressionIncreased risk of infection
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