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Target intelligence / Profile preview
Interleukin 18 (IL-18)
- Target
- IL-18
- Molecular classification
- Interleukin-1 cytokine family, Cytokine
01
Overview
Interleukin-18 (IL-18) is a pleiotropic proinflammatory cytokine essential for host defense but also implicated in pathological inflammation when dysregulated. Its biology involves tight regulation through proteolytic processing and natural inhibitory proteins that together determine net biological effects across health and disease states.
- Other names
- IL18Interleukin‐18IFN-γ inducing factor
02
Mechanism of action
Inhibition of IL-18 signaling by blocking IL-18 or enhancing IL-18 binding protein activity
03
Biological functions
Immune responseInflammationInduces IFN-γ productionActivates Th1/NK/NKT/B/DCsHost defense
04
Disease associations
Autoimmune diseasesInflammatory diseasesRheumatoid arthritisSystemic lupus erythematosusType I diabetes mellitusPsoriasisAtopic dermatitisInflammatory bowel diseaseHemophagocytic syndromeMacrophage activation syndrome
05
Safety considerations
Excessive immunosuppressionPotential for increased risk of infection
06
Interacting drugs
Anakinra
3 more in the full profile.
07
Biomarkers
Elevated circulating IL-18 levels
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