Target intelligence / Profile preview

Interleukin 2 (IL-2)

Target
IL-2
Molecular classification
Cytokine, Interleukin
01

Overview

Interleukin 2 (IL-2) is a cytokine and key immunoregulatory protein with significant roles in immune system function, particularly in T cell biology and cancer immunotherapy. It stimulates the growth, proliferation, and differentiation of T lymphocytes, B lymphocytes, and NK cells. IL-2 plays a dual role: it can have both immunostimulatory effects—enhancing immune responses—and immunoinhibitory effects—supporting regulatory mechanisms to prevent autoimmunity or excessive inflammation depending on context and target cell type.

Other names
IL2
02

Mechanism of action

Stimulates the growth, proliferation, and differentiation of T lymphocytes, B lymphocytes, and NK cells by binding to the IL-2 receptor and activating intracellular signaling pathways.

03

Biological functions

Immune responseCell proliferationCell differentiationT cell activationNK cell activationRegulation of immune tolerance
04

Disease associations

CancerAutoimmunityInflammation
05

Safety considerations

Potential for excessive immune stimulationCapillary leak syndrome
06

Interacting drugs

Aldesleukin

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