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Target intelligence / Profile preview
Interleukin 2-inducible T-cell kinase (ITK)
- Target
- ITK
- Molecular classification
- Enzyme, Protein Kinase, Tyrosine Kinase, Tec family non-receptor tyrosine kinase
01
Overview
Interleukin 2-inducible T-cell kinase (ITK) is a non-receptor tyrosine kinase belonging to the Tec family. ITK plays a crucial role in T cell signaling, activation, and differentiation, particularly in Th2, Th9, and Th17 cell effector functions. It is involved in the regulation of cytokine production and is essential for adaptive immunity. ITK is activated downstream of the T cell receptor (TCR) and phosphorylates key substrates like PLCγ1 and LAT/LCP2, leading to calcium flux, NFAT activation, and downstream signaling cascades involved in lymphokine production, proliferation, and differentiation. ITK is a therapeutic target for autoimmune diseases, allergic disorders, and certain cancers.
- Other names
- Tyrosine-protein kinase ITK/TSKEMTLYKLPFS1
02
Mechanism of action
ATP-competitive inhibition of ITK kinase activity
03
Biological functions
Adaptive immunity regulationT-cell developmentT-cell activationT-cell proliferationT-cell differentiationCytokine productionSignal transduction
04
Disease associations
ImmunodeficiencyLymphoproliferative disordersAutoimmune diseasesAllergic inflammationAsthmaCancer
05
Safety considerations
Potential for immunosuppressionOff-target effects due to structural similarity with other kinases
06
Interacting drugs
Ibrutinib
1 more in the full profile.
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