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Target intelligence / Profile preview
Interleukin-2 Pathway (IL-2 Pathway)
- Target
- IL-2 Pathway
- Molecular classification
- Signaling Pathway
01
Overview
The Interleukin-2 (IL-2) pathway is a critical immune signaling cascade primarily involved in the regulation, growth, and differentiation of T cells, B cells, natural killer (NK) cells, and other immune cell types. IL-2 is a cytokine mainly produced by activated CD4+ T cells but can also be secreted by dendritic cells and B cells. The pathway is initiated by IL-2 binding to its receptor complex (IL-2R), leading to activation of downstream signaling pathways like JAK-STAT, PI3K/Akt/mTOR, and MAPK/ERK. It plays crucial roles in both pro-inflammatory responses and immune tolerance. Dysregulation can result in immunodeficiency or autoimmunity, and recombinant IL-2 is used therapeutically to boost immune responses against cancers.
- Other names
- IL2 PathwayIL-2 Signaling Cascade
02
Mechanism of action
Recombinant IL-2 binds to IL-2 receptors, stimulating immune cell proliferation and activity.
03
Biological functions
T cell proliferationT cell differentiationT cell survivalRegulatory T cell developmentNK cell activationB cell modulationImmune response regulationSignal transduction
04
Disease associations
ImmunodeficiencyAutoimmune disordersCancer
05
Safety considerations
High-dose IL-2 can cause severe systemic toxicity.Potential for cytokine release syndrome.
06
Interacting drugs
Recombinant human IL-2
07
Biomarkers
sCD25 (soluble CD25)
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