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Target intelligence / Profile preview
Interleukin-2 Receptor (IL-2R)
- Target
- IL-2R
- Molecular classification
- Receptor, Heterotrimeric protein complex
01
Overview
The interleukin-2 receptor (IL-2R) is a heterotrimeric protein complex expressed on the surface of certain immune cells, primarily lymphocytes. It binds to the cytokine interleukin-2 (IL-2), playing a central role in regulating immune responses, including T cell activation, proliferation, and differentiation.
- Other names
- IL-2RαCD25Tac antigenIL-2RβCD122IL-2Rγcommon gamma chainγcCD132
02
Mechanism of action
Binding to IL-2R triggers intracellular signaling cascades (JAK–STAT, PI3K–AKT, MAPK) leading to gene expression and cellular responses.
03
Biological functions
Immune regulationT cell activationT cell proliferationT cell differentiationB cell activationB cell proliferationB cell differentiationNatural killer (NK) cell activationNatural killer (NK) cell proliferationNatural killer (NK) cell differentiationSignal transduction
04
Disease associations
Autoimmune diseases (e.g., sarcoidosis)Cancers/tumor diseasesOrgan rejection post-transplantationInfections
05
Safety considerations
Dose-dependent toxicity due to broad effects on multiple immune cell types through different receptor configurations
06
Interacting drugs
Recombinant human IL-2
07
Biomarkers
Soluble IL-2Rα
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