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Target intelligence / Profile preview
Interleukin-2 Receptor Alpha (IL-2Rα)
- Target
- IL-2Rα
- Molecular classification
- Type I transmembrane protein, Receptor
01
Overview
Interleukin-2 receptor alpha (IL-2Rα), also known as CD25 or Tac antigen, is a type I transmembrane protein that forms part of the high-affinity interleukin-2 (IL-2) receptor complex on immune cells. It plays a crucial role in regulating immune responses, particularly T cell proliferation and the function of regulatory T cells (Tregs). A soluble form of IL-2Rα (sIL-2Rα) serves as a biomarker for immune system activation.
- Other names
- CD25Tac antigenIL2RA
02
Mechanism of action
IL-2Rα binds IL-2, facilitating the formation of the high-affinity IL-2 receptor complex, which then triggers downstream signaling pathways affecting T cell proliferation and function.
03
Biological functions
Immune regulationT cell proliferationRegulatory T cell functionLigand bindingSignal transduction
04
Disease associations
Autoimmune disordersLymphomasLeukemiasTransplant rejectionInflammation
05
Biomarkers
sIL-2Rα (soluble form)
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