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Target intelligence / Profile preview
Interleukin-2 Receptor Alpha Subunit (IL-2Rα)
- Target
- IL-2Rα
- Molecular classification
- Type I transmembrane glycoprotein, Receptor
01
Overview
The interleukin-2 receptor alpha subunit (IL-2Rα), also known as CD25, is a component of the interleukin-2 receptor complex, which plays a central role in regulating immune responses. It is a type I transmembrane protein that binds IL-2 and increases the affinity of the receptor complex. IL-2Rα is essential for T cell proliferation, survival, and the function of regulatory T cells. Its expression is upregulated on activated T cells, and its soluble form can be used as a biomarker of immune activation.
- Other names
- CD25Tac antigenIL2RA
02
Mechanism of action
Targeting IL-2Rα can modulate T cell activity and immune responses. Drugs that block IL-2Rα can suppress immune responses in autoimmune diseases or prevent transplant rejection. Conversely, drugs that activate IL-2 signaling through the receptor complex can enhance immune responses in cancer immunotherapy.
03
Biological functions
Binds interleukin-2High-affinity IL-2 receptor formationT cell proliferationImmune regulationMaintenance of self-toleranceSignal transduction
04
Disease associations
AutoimmunityCancerInflammationImmune dysregulation
05
Safety considerations
Blocking IL-2Rα can lead to immunosuppression and increased risk of infection.Altering IL-2 signaling can have complex and potentially detrimental effects on the immune system.
06
Biomarkers
Soluble IL-2Rα levels in serum correlate with immune activation and certain neoplastic conditions.
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