Interleukin-2 receptor and Interleukin-15 receptor (IL-2R and IL-15R)

Interleukin-2 receptor and interleukin-15 receptor are structurally related heteromeric complexes that mediate signal transduction for their respective cytokines, IL-2 and IL-15, driving immune cell proliferation, survival, and differentiation[1][2][4][5]. Both receptors utilize a shared β subunit (CD122) and the common γ-chain (CD132), but are differentiated by their unique α subunits (IL-2Rα/CD25 for IL-2R, IL-15Rα/CD215 for IL-15R), which confer high affinity and specificity[1][2][3]. These receptors are critical in regulating T cell and natural killer (NK) cell biology, and play pivotal roles in immune response, tolerance, and homeostasis[4][6]. Therapeutically, they are targeted by monoclonal antibodies, recombinant cytokines, and immunotoxins in cancer, transplantation, and autoimmune diseases; manipulation of these pathways is powerful but carries significant immunological risks[4][5]. If you need information for only one receptor specifically (IL-2 receptor or IL-15 receptor), more granular data is available by splitting the query.

Other names

IL-2 receptor: CD25 (IL-2Rα)CD122 (IL-2Rβ)CD132 (common γ-chain)IL-15 receptor: CD215 (IL-15Rα)CD122 (IL-2/IL-15Rβ)Interleukin-2 receptorInterleukin-15 receptorIL2RIL15R

Inhibition of IL-2 or IL-15 mediated signaling (antagonists) Activation/expansion of immune cells, especially T and NK cells (agonists) Targeted delivery of cytotoxic drugs to IL-2R or IL-15R expressing cells