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Target intelligence / Profile preview
Interleukin 2 Receptor Beta-Gamma (IL-2Rβγ)
- Target
- IL-2Rβγ
- Molecular classification
- Receptor, Cytokine Receptor, Type I cytokine receptor family
01
Overview
The interleukin-2 receptor beta-gamma (IL-2Rβγ) is a heterodimeric cell surface receptor complex composed of the beta (CD122) and gamma (CD132) subunits. This complex mediates cellular responses to interleukin-2 (IL-2), crucial for immune cell proliferation, differentiation, and activation. It is found primarily on memory T cells and NK cells, and its selective targeting can enhance anti-tumor immunity while minimizing toxicity.
- Other names
- IL-2RbgIL2RβγCD122/CD132IL-2Rb/g
02
Mechanism of action
Agonist binding leads to JAK/STAT pathway activation, resulting in T cell and NK cell proliferation and activation.
03
Biological functions
Signal transductionImmune responseT cell proliferationNK cell activationCytokine signaling
04
Disease associations
CancerImmunodeficiencyAutoimmunityInflammation
05
Safety considerations
Potential for cytokine release syndromeOff-target effects on other immune cellsImmunogenicity of engineered ligandsExpansion of regulatory T cells (if α subunit is also targeted)
06
Interacting drugs
IL-2
3 more in the full profile.
07
Biomarkers
CD122 expressionCD132 expressionSTAT phosphorylationT cell proliferationNK cell activation
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