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Target intelligence / Profile preview
Interleukin-2 Receptor Beta Gamma Complex (IL-2Rβγ)
- Target
- IL-2Rβγ
- Molecular classification
- Receptor, Cytokine receptor complex, Type I cytokine receptor
01
Overview
The interleukin-2 receptor (IL-2R) beta gamma complex refers to the combination of the IL-2 receptor beta (IL-2Rβ, CD122) and common gamma chain (γc, CD132), which together form an intermediate-affinity binding site for interleukin-2 (IL-2). It is crucial for signal transduction, lymphocyte proliferation, and immune homeostasis. Defects can lead to immunodeficiency, while therapeutic targeting is explored for cancer immunotherapy and autoimmune diseases.
- Other names
- IL-2R beta gammaIL-2RβγCD122/CD132 complexIL-2 receptor intermediate affinity
02
Mechanism of action
Agonist: Promotes receptor dimerization and downstream signaling; Antagonist: Blocks IL-2 binding and signaling
03
Biological functions
Signal transductionImmune responseCell proliferationLymphocyte survivalT cell activationNK cell activationRegulation of immune homeostasis
04
Disease associations
ImmunodeficiencyAutoimmune diseasesCancer
05
Safety considerations
Potential for cytokine stormImmunogenicity of engineered variants
06
Interacting drugs
IL-2
1 more in the full profile.
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