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Target intelligence / Profile preview
Interleukin 2 Receptor Beta Subunit (IL-2Rβ)
- Target
- IL-2Rβ
- Molecular classification
- Type I cytokine receptor, Receptor
01
Overview
The interleukin-2 receptor beta subunit (IL-2Rβ), also known as CD122, is a type I membrane protein that forms a critical component of the interleukin-2 receptor complex. It plays an essential role in mediating immune responses, particularly those involving T cells and natural killer (NK) cells. It binds interleukin-2 (IL-2) as part of the multi-subunit complex and also participates in the interleukin-15 receptor complex. Therapeutic manipulation of this pathway has been central both for immunostimulation (e.g., cancer immunotherapy using recombinant human IL-2) and immunosuppression strategies.
- Other names
- CD122IL2RBIL15RBP70-75
02
Mechanism of action
Agonism (with IL-2), modulation of IL-2 signaling
03
Biological functions
Signal transductionImmune responseCell proliferationReceptor-mediated endocytosisT cell activationNK cell activationRegulation of immune homeostasis
04
Disease associations
CancerInflammationAutoimmune diseases
05
Safety considerations
Cytokine release syndrome (CRS)Immune-related adverse events (irAEs)Toxicity associated with high-dose IL-2
06
Interacting drugs
Recombinant human IL-2 (e.g., Aldesleukin)
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