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Target intelligence / Profile preview
Interleukin-2 Receptor Complex (IL-2R)
- Target
- IL-2R
- Molecular classification
- Receptor, Cytokine Receptor, Type I Cytokine Receptor
01
Overview
The interleukin-2 receptor complex (IL-2R) is a heterotrimeric protein complex composed of alpha (CD25), beta (CD122), and gamma (CD132) subunits. It is expressed on immune cells, particularly lymphocytes, and mediates cellular responses to interleukin-2 (IL-2). IL-2R plays a crucial role in immune regulation, T cell proliferation, and maintenance of self-tolerance. The high-affinity form of the receptor, containing all three subunits, is essential for optimal IL-2 signaling. The soluble form of the alpha subunit (sCD25) can be used as a biomarker for immune activation.
- Other names
- IL2RInterleukin 2 ReceptorCD25 complexCD122 complexCD132 complex
02
Mechanism of action
Modulation of IL-2 signaling pathway, including inhibition of receptor binding or downstream signaling events.
03
Biological functions
Signal transductionImmune responseT cell proliferationCell survivalRegulation of immune tolerance
04
Disease associations
Autoimmune diseasesCancerInflammationImmunodeficiency
05
Safety considerations
ImmunosuppressionOpportunistic infectionsCytokine release syndrome
06
Biomarkers
sCD25 (soluble IL-2R alpha)CD25 expression on T cells
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