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Target intelligence / Profile preview
Interleukin 2 Receptor Gamma (IL-2Rγ)
- Target
- IL-2Rγ
- Molecular classification
- Receptor, Cytokine Receptor, Type I cytokine receptor family
01
Overview
The interleukin-2 receptor gamma chain (IL-2Rγ), also known as the common gamma chain (γc) or CD132, is a critical component of several cytokine receptors, including those for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. It is essential for lymphocyte development and signaling through the JAK/STAT pathway. Mutations in the *IL2RG* gene cause X-linked Severe Combined Immunodeficiency (X-SCID).
- Other names
- Common gamma chainCD132Common cytokine receptor gamma chainGamma-CSCIDXSCIDX1XSCIDγc
02
Mechanism of action
Forms a functional receptor complex upon ligand binding, triggers JAK/STAT signaling pathway leading to gene expression regulation.
03
Biological functions
Signal transductionLymphocyte developmentT cell growth/differentiationB cell differentiationMast cell functionNK/T cell homeostasisB/T/NK cell regulation
04
Disease associations
X-linked Severe Combined Immunodeficiency (X-SCID)ImmunodeficiencyInfection
05
Safety considerations
Toxicity due to broad immune activation via shared cytokine pathwaysOff-target effects of interleukin therapies
06
Interacting drugs
Recombinant human interleukins (e.g., IL-2, IL-4, IL-7, IL-9, IL-15, IL-21)
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