Interleukin-2 receptor subunit gamma mRNA (IL2RG mRNA)

Interleukin-2 receptor subunit gamma (IL2RG) mRNA encodes the common cytokine receptor gamma chain (gamma-c), a vital component of the receptor complexes for several interleukins, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 [1, 2]. This protein is indispensable for the maturation and differentiation of lymphocytes, particularly T cells and natural killer (NK) cells, by facilitating signal transduction through the Janus kinase (JAK) 3 pathway [3]. Deficiencies or mutations in the IL2RG gene result in X-linked severe combined immunodeficiency (X-SCID), a life-threatening condition where the immune system is profoundly compromised, leaving patients susceptible to severe, recurrent infections [4]. Therapeutic interventions targeting IL2RG mRNA primarily involve ex vivo gene therapies designed to restore the production of functional gamma-c protein in hematopoietic stem cells [5]. Modern clinical approaches utilize self-inactivating lentiviral vectors to deliver the functional IL2RG sequence, aiming to provide a curative treatment while reducing the historical risk of insertional oncogenesis associated with earlier retroviral methods [6].

Other names

Common gamma chain mRNACD132 mRNAIL-2RG mRNAGamma-c mRNACytokine receptor common subunit gamma mRNA

Restoration of functional common gamma chain protein expression through gene replacement or mRNA delivery to hematopoietic stem cells, enabling normal lymphocyte development and signaling [5, 6].