Target intelligence / Profile preview

Interleukin 20 (IL-20)

Target: IL-20
Molecular classification: Cytokine, Interleukin-10 family member

Overview

Interleukin 20 (IL-20) is a pro-inflammatory and angiogenic cytokine belonging to the IL-10 family. It is primarily secreted by monocytes and skin keratinocytes and plays a role in immune responses, particularly in cutaneous inflammation, and angiogenesis. Dysregulation of IL-20 is associated with diseases like atopic dermatitis, psoriasis, and dry eye disease.

Other names: IL20IL10DZCYTO10

Mechanism of action

JAK-STAT pathway activation (primarily via STAT3)

Biological functions

Pro-inflammatory signalingAngiogenesisModulation of epithelial cell biologyImmune responseRegulation of keratinocyte proliferation/differentiation

Disease associations

Atopic dermatitisPsoriasisDry eye diseaseIschemic cardiomyopathyAcute myocardial infarctionInflammatory bowel disease (potential role)

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