Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Interleukin-20 Receptor (IL-20R)
- Target
- IL-20R
- Molecular classification
- Receptor, Interleukin-10 Receptor Family, Cytokine Receptor
01
Overview
The Interleukin-20 receptor (IL-20R) is a heterodimeric receptor belonging to the IL-10 receptor family. It exists in two forms, Type I (IL20RA + IL20RB) and Type II (IL22RA1 + IL20RB), and binds to interleukins 19, 20, and 24. Signaling primarily occurs through the JAK-STAT pathway, influencing epithelial cell proliferation, wound healing, inflammation, and other processes. Dysregulation of IL-20R signaling is implicated in diseases like psoriasis, rheumatoid arthritis, atherosclerosis, and cancer.
- Other names
- IL20RIL-20 receptor complexInterleukin 20 receptor
02
Mechanism of action
JAK-STAT pathway modulation
03
Biological functions
Signal transductionEpithelial cell proliferationWound healingPrevention of apoptosisRegulation of inflammationHematopoietic progenitor cell expansion/differentiationAngiogenesisMucosal immunity
04
Disease associations
PsoriasisRheumatoid arthritisAtherosclerosisOsteoporosisCancerInflammatory bowel diseaseAutoimmune diseases
05
Safety considerations
Potential for pro-tumorigenic or anti-tumorigenic effects depending on contextPotential for exacerbating or ameliorating autoimmune diseases depending on contextOff-target effects due to shared subunits with other cytokine receptors
Beyond the preview
Go deeper on Interleukin-20 Receptor (IL-20R).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Interleukin-20 Receptor (IL-20R).