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Target intelligence / Profile preview
Interleukin-21 (IL-21)
- Target
- IL-21
- Molecular classification
- Type I cytokine family, Cytokine
01
Overview
Interleukin-21 (IL-21) is a pleiotropic type I cytokine primarily produced by activated CD4+ T cells. It plays a crucial role in modulating both innate and adaptive immune responses by influencing the differentiation, proliferation, and activity of various immune cells, including B cells, T cells, NK cells, and dendritic cells. IL-21 signals through a heterodimeric receptor complex composed of IL-21Rα and γc/CD132, activating the JAK/STAT signaling pathway. Targeting the IL-21/IL-21R axis holds therapeutic potential for cancer immunotherapy and the treatment of autoimmune and inflammatory diseases.
- Other names
- IL21
02
Mechanism of action
Modulation of immune cell activity via JAK/STAT signaling pathway
03
Biological functions
Immune responseCell proliferationCell differentiationB-cell differentiationT-cell proliferationNK cell activationPlasma cell generationRegulation of IgE class switch recombination
04
Disease associations
AutoimmunityCancerAllergyInfectionInflammation
05
Safety considerations
Potential for immune-related adverse events due to broad immunomodulatory effectsRisk of cytokine storm
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