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Target intelligence / Profile preview
Interleukin 22 Receptor (IL-22R)
- Target
- IL-22R
- Molecular classification
- Type II cytokine receptor, Class II cytokine receptor family, Receptor, Heterodimeric receptor
01
Overview
The Interleukin-22 receptor (IL-22R) is a type II cytokine receptor that mediates the biological effects of interleukin-22 (IL-22). The functional IL-22 receptor complex is a heterodimer composed of IL-22R1 and IL-10R2. Upon ligand engagement, the receptor complex activates JAK/STAT and other signaling pathways, leading to transcriptional activation and diverse biological responses including epithelial barrier maintenance, antimicrobial peptide production, tissue repair, and inflammation modulation. Dysregulation of IL-22R signaling is implicated in autoimmune diseases.
- Other names
- IL-22 ReceptorInterleukin-22 ReceptorIL22RIL-22RA1/IL-10R2 complexInterleukin ‑ 22 receptor alpha chain
02
Mechanism of action
JAK/STAT signaling pathway activation
03
Biological functions
Signal transductionEpithelial barrier integrityAntimicrobial peptide productionTissue repairWound healingInflammation modulationCell survivalCell proliferation
04
Disease associations
Autoimmunity (psoriasis, rheumatoid arthritis, SLE)InflammationInfection
05
Safety considerations
Potential for excessive pro-inflammatory activityImpaired tissue protection/regeneration
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