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Target intelligence / Profile preview
Interleukin 22 Receptor Alpha 1 Subunit (IL-22RA1)
- Target
- IL-22RA1
- Molecular classification
- Receptor, Class II Cytokine Receptor
01
Overview
IL-22RA1 is a subunit of the IL-22 receptor complex, a member of the class II cytokine receptor family. It mediates cellular responses to IL-22, IL-20 and IL-24, primarily in epithelial cells. Activation of IL-22RA1 triggers downstream signaling pathways, including JAK/STAT, MAPK, and Akt, leading to upregulation of antimicrobial peptides, induction of acute phase proteins, and promotion of tissue repair. It is expressed in epithelial-rich tissues such as skin, gut, and lung, and plays a key role in innate immunity and tissue homeostasis. It has been studied as a biomarker for inflammatory conditions.
- Other names
- CRF2–9IL22RIL22R1Cytokine receptor class-II member 9ZcytoR11
02
Mechanism of action
Antibodies targeting IL-22RA1 block ligand binding and downstream signaling.
03
Biological functions
Signal transductionInnate immunityWound healingAntimicrobial responseJAK/STAT signaling pathwayMAPK signaling pathwayAkt signaling pathway
04
Disease associations
InflammationInfection
05
Biomarkers
Biomarker for inflammatory conditions
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