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Target intelligence / Profile preview
Interleukin 22 Receptor Subunit Alpha (IL22RA)
- Target
- IL22RA
- Molecular classification
- Receptor, Class II cytokine receptors, Integral membrane protein, Soluble receptor (IL22RA2)
01
Overview
Interleukin 22 Receptor Subunit Alpha (IL22RA) refers to two related proteins, IL22RA1 and IL22RA2, which play distinct roles in immune signaling. IL22RA1 is a membrane-bound receptor subunit that forms a functional receptor complex with IL10RB to mediate cellular responses to IL-22, IL-20, and IL-24. This complex activates JAK/STAT, MAPK, and Akt signaling pathways, influencing inflammation, tissue protection, and host defense. IL22RA2, also known as IL-22BP, is a soluble antagonist that binds IL-22, preventing it from activating the IL22RA1 complex. Altered expression or function of IL22RA is linked to various inflammatory conditions, making it a potential therapeutic target.
- Other names
- IL22RA1IL22RA2IL22RIL22R1CRF2-9Cytokine receptor class-II member 9ZcytoR11IL-22BP
02
Mechanism of action
Modulation of IL-22 signaling pathway
03
Biological functions
Signal transductionImmune responseTissue repairInflammationAntiangiogenic activityRegulation of epithelial immunity
04
Disease associations
InflammationAutoimmune diseasesUveitisOther inflammatory conditions
05
Safety considerations
Potential for immune dysregulationOff-target effects on other cytokine pathways
06
Biomarkers
IL22RA1 expression levelsIL22RA2 levels
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