Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Interleukin 22 Receptor Subunit Alpha 1 (IL22RA1)
- Target
- IL22RA1
- Molecular classification
- Receptor, Cytokine Receptor, Class II Cytokine Receptor
01
Overview
Interleukin 22 receptor subunit alpha 1 (IL22RA1) is a key component of the interleukin receptor complexes for IL-20, IL-22, and IL-24. It forms heterodimers with other receptor subunits (IL10RB or IL20RB) to mediate signaling upon ligand binding. Activation of IL22RA1 leads to the activation of JAK/STAT, MAPK, and Akt pathways, which regulate immune responses, inflammation, and cell survival. Dysregulation of IL22RA1 has been implicated in inflammatory diseases and metabolic disorders.
- Other names
- CRF2-9IL22RIL22R1Cytokine receptor class-II member 9ZcytoR11
02
Mechanism of action
Ligand binding induces receptor dimerization and activation of downstream signaling pathways, including JAK/STAT, MAPK, and Akt.
03
Biological functions
Signal transductionImmune responseRegulation of inflammationMediates JAK/STAT pathway activationMediates MAPK pathway activationMediates Akt pathway activationCytokine binding
04
Disease associations
Inflammatory diseasesUveitisMetabolic dysregulation
05
Safety considerations
Potential for immune dysregulationPotential for off-target effects due to shared receptor subunits with other interleukins
Beyond the preview
Go deeper on Interleukin 22 Receptor Subunit Alpha 1 (IL22RA1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Interleukin 22 Receptor Subunit Alpha 1 (IL22RA1).