Interleukin-23 p19 Subunit (IL-23p19)

The Interleukin-23 p19 subunit (IL-23p19) is a key component of the IL-23 cytokine, which plays a crucial role in the maintenance and expansion of Th17 cells and the promotion of pro-inflammatory responses. IL-23p19 forms a heterodimer with the IL-12p40 subunit to create the biologically active IL-23 cytokine. By specifically targeting IL-23p19, therapeutic antibodies can selectively inhibit IL-23 signaling without affecting IL-12 activity. This approach has proven effective in treating autoimmune diseases such as psoriasis, colitis, and arthritis, where IL-23-mediated inflammation contributes significantly to disease pathology.

Other names

Interleukin-23 subunit alphaIL23A

Monoclonal antibodies bind specifically to the IL-23p19 subunit, preventing the formation of the IL-23 heterodimer and subsequent receptor binding, thereby blocking IL-23 signaling and downstream inflammatory responses.