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Target intelligence / Profile preview
Interleukin-23 Receptor (IL-23R)
- Target
- IL-23R
- Molecular classification
- Type I cytokine receptor
01
Overview
The interleukin-23 receptor (IL-23R) is a type I cytokine receptor that forms a heterodimeric complex with IL-12Rβ1. This complex binds interleukin-23 (IL-23) and initiates signaling cascades that promote the differentiation, maintenance, and expansion of Th17 cells and other immune cell subsets involved in inflammation and autoimmunity. It plays a key role in immune responses at barrier sites and is implicated in the pathogenesis of several autoimmune diseases. Therapies targeting the IL-23/IL-23R axis are used clinically for diseases like psoriasis and Crohn's disease.
02
Mechanism of action
Inhibition of IL-23/IL-23R signaling
03
Biological functions
Signal transductionImmune responseCell proliferationT cell differentiationCytokine production
04
Disease associations
InflammationAutoimmune diseaseInflammatory bowel diseasePsoriasisRheumatoid arthritis
05
Safety considerations
Increased risk of infectionPotential for immune-related adverse eventsIndividual response variability based on genetic variation
06
Interacting drugs
Monoclonal antibodies against IL-23 or IL-23R
07
Biomarkers
IL23R gene polymorphisms
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