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Target intelligence / Profile preview
Interleukin-25 (IL-25)
- Target
- IL-25
- Molecular classification
- Cytokine, Interleukin-17 family member
01
Overview
Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family and plays a significant role in regulating immune responses, particularly type 2 immunity. It orchestrates type II immune responses through its heterodimeric receptor complex across diverse tissues and has dualistic roles—in host defense against parasites/allergens but also potentially promoting pathology in allergy/cancer contexts—making it an attractive therapeutic target under active investigation.
- Other names
- IL-17E
02
Mechanism of action
Agonists or antagonists of IL-25/IL-25R axis
03
Biological functions
Immune regulationType 2 immunity inductionAllergic inflammationPathogen clearanceCytokine productionChemokine releaseCell proliferation regulationApoptosis regulation
04
Disease associations
AllergyAsthmaInfectionCancerAutoimmunity
05
Safety considerations
Potential for exacerbating allergic inflammationPotential for promoting tumor growthPotential for inhibiting IFNγ expression in viral infections
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