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Target intelligence / Profile preview
Interleukin 27 (IL-27)
- Target
- IL-27
- Molecular classification
- Cytokine, Interleukin-12 family, gp130 family, Heterodimeric protein
01
Overview
Interleukin 27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family, composed of IL-27p28 and EBI3 subunits. Produced primarily by activated antigen-presenting cells, IL-27 binds to a receptor complex of IL-27Rα and gp130, activating JAK-STAT signaling. IL-27 exhibits pleiotropic effects on T cell subsets, promoting Th1 and Tr1 differentiation while inhibiting Th2 and Th17. It enhances cytotoxicity in CD8+ T cells and supports germinal center reactions in B cells. Displaying both pro-inflammatory (IFNγ production) and anti-inflammatory (IL-10 induction) properties, therapeutic targeting of IL-27 is under investigation for infectious diseases, autoimmunity, and cancer.
- Other names
- IL27IL-27p28/EBI3 heterodimerInterleukin-27WSX-1 ligandIL-30/EBI3 heterodimer
02
Mechanism of action
Modulation of T cell differentiation and function; Regulation of cytokine production; Activation of JAK-STAT signaling pathway
03
Biological functions
Immune responseT cell differentiationRegulation of inflammationCytokine productionSignal transductionInnate immune response regulationB cell help
04
Disease associations
Infectious diseasesAutoimmunityCancerInflammation
05
Safety considerations
Potential for both pro-inflammatory and anti-inflammatory effectsRisk of cytokine storm
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